Single Use Cells (S.U.C.)

High performance single use cells for photometric and electrochemical monitoring

optek Single Use Cells have an integrated conductivity sensor and enable simultaneous electrochemical and optical measurements. Various options of line sizes and connections allow for a simple integration into bioprocessing systems from low volume research up to high volume biopharmaceutical manufacturing.

Parameters that can be measured in one single use cell:

  • Wavelength 1: UV Absorbance
  • Wavelength 2: UV Absorbance
  • Multi-range Conductivity: µS/cm
  • Multi-range Conductivity: mS/cm
  • Temperature
  • pH

Detailed monitoring of various parameters in biopharmaceutical downstream processes:

  • Clarification & Centrifugation
  • Viral Clearance
  • Chromatography
  • Virus Filtration
  • Concentration (e.g., TFF)
  • Sterile Filtration
  • Formulation & Filling

Single Use Cells (S.U.C.) are designed to optimize separation, purification and concentration processes in disposable chromatography and ultrafiltration systems. Since 2014 optek has been the industry leader for disposable measuring cell technology for use in downstream purification steps. The unique design of the optek system allows up to 6 measurements in one Single Use Cell (SUC27), conductivity, pH, temperature plus dual wavelength UV measurements from one disposable S.U.C. The combination of two S.U.C. allows PRE and POST control with 8 parameters, all displayable on an optek C8000 converter.

Features
Benefits
S.U.C. can be combined with standard optek sensors
Identical performance and handling compared to conventional sensors
Up to six measurements in one Single Use Cell
Minimized hold up volume with maximum flexibility
Various S.U.C. models with broad range of hose barb and clamp connection sizes
Optimized solution for manifold requirements
USP Class VI and FDA approval
Meets industry specific requirements
ACF60-SU-35
Material (non wetted)

SS 316L
Measuring range

0 μS/cm to 350 mS/cm

Accuracy: 0 μS/cm to 150 mS/cm: ± 2 % of measuring value ± 0.4 μS/cm

Accuracy6: 150 mS/cm to 350 mS/cm: ± 4.5 % of measuring value

(dependent on ambient and process temperature being equal)
Temperature compensation of conductivity sensor

Accuracy ≤ 0.8% of measuring value at temperature conditions (T ambient - T process) ≤ ± 20 °C (± 68 °F)
Protection

IP65
Cleanability

Cleaning with standard cleaning agents (alcoholic surface disinfectants, quaternary ammonium compounds) is permitted.

Caution! Ensure that windows are clean and dry and the contact unit for the electrodes is dry before starting measurement.
S.U.C.
Material (wetted)

Windows (SUC24, SUC25, SUC27): Quartz, UV transparent

Gasket: EPDM (FDA, USP Class VI)

Conductivity electrode pins: stainless steel 1.4435 (SS 316L), dF < 1%, BN2

Sensor body: Polyphenylsulfone (PPSU) (USP Class VI)

The plastic and elastomeric wetted parts of the sensor have passed the bio-reactivity tests according to USP <87> and <88> Class VI and the elastomeric wetted parts also comply with FDA regulation 21 CFR 177.2600. All wetted parts are of non-animal origin and any materials of animal origin or containing animal substances are not used during manufacture. All wetted parts are of bovine-free origin and any materials of bovine origin or containing TSE have not been used during manufacture.
Surface (wetted parts)

N6: Ra < 0.8 µm (32 µinch)
Process connection

Hose barb, Clamp1
Line Size

Line Size Hose barb 0.25 in., 0.375 in., 0.5 in., 0.625 in., 0.75 in., 1 in.

Line size - Clamp Mini-TC1, 2 0.25 in., 0.375 in., 0.5 in., 0.625 in.

Line size - Clamp TC1, 3 0.75 in., 1 in.
Optical Path Length (OPL)4

1 mm, 2.5 mm, 10 mm, 20mm
Shelf life

36 months after manufacturing date with adequate storage climatic conditions5
Permitted gamma or X-ray irradiation

Tested to 55 kGy
Temperature and Pressure Ratings
Process pressure

0 - 6 bar (0 - 87 psi) May be reduced in combination with pH probe. Refer to corresponding instruction manual for specifications of pH probe.
Process temperature

2 - 50 °C (35.6 - 122 °F) May be reduced in combination with pH probe. Refer to corresponding instruction manual for specifications of pH probe.
Ambient conditions

Temperature during operation: 2 - 30 °C (35.6 - 86 °F)

Relative humidity 80 % for temperature up to 31 °C (87 °F)
Storage conditions

Temperature: 15 – 25 °C (59 – 77 °F).

Relative humidity: max. 60%

No exposure to fumes.
Pressure and temperature ratings specified herein may be subject to limitations - see instruction manual. The appropriate choice of material for all wetted parts is the sole responsibility of the user. Data given are subject to changes without prior notice.

  • 1) Clamps according to ASME BPE Design Standard 2016, Table DT-7-1, IMPORTANT: Deviating from the ASME BPE design standard, the line size of the S.U.C. clamp is referring to the internal diameter or bore, NOT the external tube diameter.
  • 2) Flange Type A, Diameter 0.984 in., “Mini-TC”.
  • 3) Flange Type B, Diameter 1.984 in., “TC”.
  • 4) Valid only for SUC24, SUC25 and SUC27
  • 5) See: Storage conditions
  • 6) From delivery 01.01.2018.
S.U.C. Types Conductivity pH Optical Hold-up Volume Example
SUC21 checkmark - - 20 ml
SUC23 checkmark checkmark - 20 ml
SUC24 - - checkmark
  • OPL 1 mm: 9.2 ml
  • OPL 2.5 mm: 9.7 ml
  • OPL 10 mm: 12 ml
  • OPL 20 mm: 15 ml
SUC25 checkmark - checkmark
  • OPL 1 mm: 22 ml
  • OPL 2.5 mm: 23 ml
  • OPL 10 mm: 25 ml
  • OPL 20 mm: 28 ml
SUC27 checkmark checkmark checkmark
  • OPL 1 mm: 22 ml
  • OPL 2.5 mm: 23 ml
  • OPL 10 mm: 25 ml
  • OPL 20 mm: 28 ml

Single Use Cells Product Information

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