All bioprocesses can benefit from reduced costs, improved product quality and increased productivity. optek inline photometric analyzers provide real time knowledge needed to optimize the most demanding bioprocess. This means reliable, accurate measurements with high repeatability, linearity, and resolution.
Ultra-sanitary, stainless steel sensor bodies are designed to handle the toughest process environments and CIP/SIP. NIST-traceable, inline validation filters provide fast and repeatable measurement verification without breaching sterility. optek sensors conform to FDA requirements and are designed for cGMP facilities.
optek process instruments meet the highest demands of the biotech industry, batch after batch, week after week.
Biotechnology
Fermentation
Sanitary fermentation and cell culture applications can be optimized with the help of specially designed optek photometric probes. These probes precisely measure cell growth/biomass as a function of NIR absorption. This gives the process operator the real-time knowledge needed to optimize the bioprocess cycle.
optek probes provide a stable and reliable measurement, even in systems with a high degree of aeration or agitation. Autoclavable or CIP/SIP, optek probes are specially engineered for use in laboratory- pilot- or production -scale fermentors/bioreactors.
optek cell density probes (CDP's) eliminate the need for sampling. Direct, real-time measurement of cell density eliminates volume loss and dilution errors in addition to reducing the risk of contamination. optek cell density probes and sensors provide powerful growth trend information, allowing you to automate manual operations and achieve a new level of productivity and process control.
Proven Fermentation Applications
TCD (Total Cell Density) OD (Optical Density)
Yeast, Mammalian and Bacterial
Nutrient Feeding
Temperature Inductions
Inducer Additions
Early Detection of Deviations from Normal Growth
Harvest Timing
Process End Point Determination
Vessel-to-Vessel Product Transfers
Propagation Train Transfers
Perfusion Rate Control
Real-time Sampling
Separation
Inline photometry significantly increases yield in centrifugal separators and improves product quality. Commonly installed upstream and downstream to the separation equipment, optek photometric analyzers measure the integrity and performance of separation to improve process balance and control.
optek photometers feature a high dynamic range and can compensate for background solids. Ensuring peak separation performance is the key to maximizing product yields and streamlining downstream processes. optek instruments can help you to improve efficiency and reduce costs throughout the separation process.
Proven Separation Applications
Feed Line Solids Monitoring
Flow and Feed Control
De-Sludge Cycle Control
Centrate Line Solids Monitoring (Cell Debris)
Concentrate Line Solids and Weight Correlation
Filtration
Inline, real time monitoring with optek sensors can easily increase the productivity and performance of UF/MF/RO filtration systems. Installing optek sensors to monitor the feed, retentate and permeate lines can maximize yields, extend filter life, and minimize product loss.
optek photometric analyzers can determine the point at which acceptable purity is achieved or detect a filter upset or breakthrough. This allows for immediate notification of the problem as it occurs saving product quality and reducing downtime. otpek sensor measurements are easily correlated to lab analysis of the process stream.
For improved filtration time, increased productivity, better product consistency, and reduced operating costs, let optek photometers go to work for you.
Proven Filtration Applications
Feed Solids and Concentration Load
Feed Recirculation
Permeate Flow to Drain
Permeate Filter Breakdown and Carryover
Retentate Recirculation
Feed Flow Rate and Pressures
Permeate Line Trace Containments
Eliminating bulk collection for laboratory analysis
Retentate Concentration and Peaks
Protein Concentration and End Point
Chromatography
When chromatography is used for purification, accurate and repeatable data is essential. Precise optical density measurement can allow more aggressive pooling control to maximize yields and improve quality. optek process instruments can provide biopharmaceutical manufacturers repeatable and reliable inline measurements needed to gain the highest level of separation performance and maximize fraction yield.
Applied to nearly any type of non-adsorptive and adsorptive chromatography such as gel-filtration or Size-Exclusion Chromatography (SEC), Ion Exchange Chromatography (IEC), Hydrophobic Interaction Chromatography (HIC) and Affinity Chromatography, optek provides a wide variety of inline photometric and electro-chemical sensors designed specifically for real time chromatographic measurement and control.
Proven Chromatography Applications
Bubble Detection
Protein Concentration
pH and Conductivity
Fermentation
Many Fermentation processes, such as the production of Ethanol, are currently limited by the inability to measure parameters on-line, such as substrate, product, and biomass concentrations.
Instead of rapid and consistent feedback, manual sampling must be done off-line, resulting in inefficient process analysis and less than optimal processes.
With optek photometric analyzers, inline real-time process monitoring and automated control can be achieved. This provides increased precision, reliability, and cost effectiveness.
Besides Ethanol, other biomass sources are gaining popularity in the production of chemicals, fuels and power generation. This biomass production can also benefit from the advantages of optek inline process instruments.
Proven Fermentation Applications
Biomass Concentration
Fermentation Monitoring
Yeast Propagation Monitoring
Dehydration-Monitoring
Denaturant Monitoring
Mash Separation Monitoring
Setback Evaporator Monitoring
Residual COD Monitoring
Blood Sciences
High accuracy and reliability is a must in the processing of blood and plasma. The extreme precision offered by optek inline photometers provide real-time color monitoring for unprecedented control in various applications critical to the medical industry.
optek probes satisfy the demanding validation requirements of the medical industry with integrated validation filter ports that accommodate an optional NIST-traceable filter.
Proven Blood Sciences Applications
Hemoglobin Diafiltration
Fractionation
Purification
Cosmetic & Personal Care
From makeup to mouthwash, the manufacturing of cosmetics and personal care products benefits from the accurate and consistent measurements of optek inline photometric analyzers.
optek process instruments can help assure the color, concentration and consistency that consumer products demand.
All bioprocesses can benefit from reduced costs, improved product quality and increased productivity. optek inline photometric analyzers provide real time knowledge needed to optimize the most demanding bioprocess. This means reliable, accurate measurements with high repeatability, linearity, and resolution.
