Worldwide Inline Process Control Solutions

Single Use Cell (S.U.C.)

  • Same performance as conventional systems
  • Compatible with various optek sensors
  • Reduced risk of contamination
  • Four measurements in one Single Use Cell
  • Minimized hold-up volume
  • USP Class VI and FDA approval

Overview

The Single Use Cell (S.U.C.) is designed to optimize separation, purification, concentration and formulation processes in disposable chromatography and ultrafiltration systems.

Cross-contamination between products and batches will no longer be an issue as gamma irradiated Single Use Cells decrease the risk of contamination to virtually zero.

S.U.C. Design

The S.U.C. is available in four different designs. Two versions are primarily for pre-column chromotography measurements (SUC 01/03) and two versions for post-column measurements (SUC 05/07) with optical windows for optek UV sensors.

Each S.U.C. is clearly labeled with data specific to that particular cell. This data includes the sensor constant of the conductivity sensor, as well as the UV OPL (optical path length) adaptation data (for SUC 05/07).

  • 8 Measurements
  • 5 Sensors
  • 2 Single Use Cells
  • 1 Converter

S.U.C. Holder

Integral parts of the S.U.C. system include the holder and locking mechanism guaranteeing proper installation. To enable easy and fast installation into the process instrumentation, the S.U.C. holder comes equipped with the conductivity sensor ACF60-SU-35.

S.U.C. pH Adapter

SUC 03 and SUC 07 are equipped with the pH adapter, which is compatible with a broad variety of standard pH electrodes (Ø12 mm x 120 mm). When no pH adapter is required (for SUC 01 and SUC 05) a plug is used to cover the pH input. This pH plug has the same dimensions as the pH electrode, keeping the hold-up volume minimal.

S.U.C. (Single Use Cells)

Fully assembled SUC 07 for measuring conductivity, pH, UV and temperature

The versatile design of the optek S.U.C. has been developed to meet the specific demands of biopharmaceutical manufacturing. With low hold-up volumes and easy installation they are fully compatible with the optek range of UV, NIR and color absorption sensors.

  • The Single Use Cells are manufactured in a clean room facility and are gamma irradiation ready
  • Simple fast exchange of the S.U.C. eliminates the need for system cleaning and validation
  • Improved productivity due to simpler exchange procedures and low down time between products/batches
Available Models
S.U.C. Types Conductivity pH UV Hold-up Volume Example
SUC 01 checkmark - - 20 ml
SUC 03 checkmark checkmark - 20 ml
SUC 05 checkmark - checkmark
  • (OPL 1 mm): 22 ml
  • (OPL 2.5 mm): 23 ml
  • (OPL 10 mm): 25 ml
SUC 07 checkmark checkmark checkmark
  • (OPL 1 mm): 22 ml
  • (OPL 2.5 mm): 23 ml
  • (OPL 10 mm): 25 ml

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Technical Data

ACF60-SU-35
Material (non wetted)

SS 316 L

Measuring range

0 μS/cm to 150 mS/cm

Accuracy: ± 2 % of measuring value ± 0.4 μS/cm

(dependent on ambient and process temperature being equal)

Temperature compensation of conductivity sensor

Accuracy ≤ 0.8 % of measuring value at temperature conditions (T ambient - T process) ≤ ± 20 °C (± 68 °F)

Protection

IP65

Cleanability

Cleaning with standard cleaning agents (alcoholic surface disinfectants, quaternary ammonium compounds) is permitted.

Caution! Ensure that windows are clean and dry and the contact unit for the electrodes is dry before starting measurement.

Pressure and temperature ratings specified herein may be subject to limitations - see instruction manual. The appropriate choice of material for all wetted parts is the sole responsibility of the user. Data given are subject to changes without prior notice.
S.U.C.
Material (non wetted)

Adhesive: Epoxy LOCTITE M-31CL

Material (wetted)

Windows (SUC 05, SUC 07): Quartz, UV transparent

Gasket: EPDM (FDA, USP Class VI)

Conductivity electrode pins: stainless steel 1.4435 (SS 316L), dF < 1%, BN2

Sensor body: Polyphenylsulfone (PPSU)

The plastic and elastomeric wetted parts of the sensor have passed the bio-reactivity tests according to USP <87> and <88> Class VI and comply with FDA Regulations 21 CFR 177.2600. All wetted parts are of non-animal origin and any materials of animal origin or containing animal substances are not used during manufacture. All wetted parts are of bovine-free origin and any materials of bovine origin or containing TSE have not been used during manufacture.

Surface (wetted parts)

Ra < 0.8 µm

Process connection

Hose barb

Line Size

1/4 in., 3/8 in., 1/2 in., 5/8 in., 3/4 in., 1 in.

OPL (SUC 05, SUC 07)

1 mm, 2.5 mm, 10 mm, … others on request

Shelf life

36 months after manufactoring date with adequate storage climatic conditions

Permitted gamma irradiation

typical 25 - 40 kGy (tested to 50 kGy)

Temperature and Pressure Ratings
Process pressure

0 - 6 bar (0 - 87 psi) May be reduced in combination with pH probe. Refer to corresponding instruction manual for specifications of pH probe.

Process temperature

2 - 50 °C (35.6 - 122 °F) May be reduced in combination with pH probe. Refer to corresponding instruction manual for specifications of pH probe.

Ambient conditions

Temperature during operation: 2 - 30 °C (35.6 - 86 °F)

Relative humidity 80 % for temperature up to 31 °C (87 °F)

Pressure and temperature ratings specified herein may be subject to limitations - see instruction manual. The appropriate choice of material for all wetted parts is the sole responsibility of the user. Data given are subject to changes without prior notice.

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